Symbol
Name
ID

Ptch1
patched 1
MGI:105373

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Abnormality of the spleen
Disease(s) Associated with PTCH1	Abnormality of the spleen
holoprosencephaly

Mouse Phenotypes

abnormal thymus lobule morphology

thymus hypoplasia

abnormal hematopoietic system morphology/development

decreased immature B cell number

decreased transitional stage B cell number

abnormal double-negative T cell morphology

increased double-negative T cell number

decreased double-positive T cell number

increased neutrophil cell number

increased mature B cell number

decreased B cell number

decreased pre-B cell number

increased B cell number

increased single-positive T cell number

decreased lymphocyte cell number

Availability

Mouse Genotype

Ptch1^tm1Bjw/Ptch1^tm1Bjw
Tg(KRT14-cre)8Brn/0 (conditional)

Ptch1^tm1Hahn/Ptch1^tm1Hahn
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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